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Adherens junction remodelling during mitotic rounding of pseudostratified epithelial cells

Aguilar‐Aragon, Mario; Bonello, Teresa; Bell, Graham P.; Fletcher, Georgina; Thompson, Barry


Epithelial cells undergo cortical rounding at the onset of mitosis to enable spindle orientation in the plane of the epithelium. In cuboidal epithelia in culture, the adherens junction protein Ecadherin recruits Pins/LGN/GPSM2 and Mud/NuMA to orient the mitotic spindle. In the pseudostratified columnar epithelial cells of Drosophila, septate junctions recruit Mud/NuMA to orient the spindle, while Pins/LGN/GPSM2 is surprisingly dispensable. We show that these pseudostratified epithelial cells...[Show more]

CollectionsANU Research Publications
Date published: 2020
Type: Journal article
Source: EMBO Reports
DOI: 10.15252/embr.201949700
Access Rights: Open Access


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