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Photocrosslinked methacrylated poly(vinyl alcohol)/hydroxyapatite nanocomposite hydrogels with enhanced mechanical strength and cell adhesion

Zhou, Ding; Dong, Qi; Liang, Kaili; Xu, Weilin; Zhou, Yingshan; Xiao, Pu

Description

Poly(vinyl alcohol) (PVA) hydrogels with high water content, good load‐bearing property, low frictional behavior as well as excellent biocompatibility have been considered as promising cartilage replacement materials. However, the lack of sufficient mechanical properties and cell adhesion are two critical barriers for their application as cartilage substitutes. To address these problems, herein, methacrylated PVA with low degree of substitution of methacryloyl group has been synthesized first....[Show more]

dc.contributor.authorZhou, Ding
dc.contributor.authorDong, Qi
dc.contributor.authorLiang, Kaili
dc.contributor.authorXu, Weilin
dc.contributor.authorZhou, Yingshan
dc.contributor.authorXiao, Pu
dc.date.accessioned2020-09-23T00:35:01Z
dc.identifier.issn0887-624X
dc.identifier.urihttp://hdl.handle.net/1885/211362
dc.description.abstractPoly(vinyl alcohol) (PVA) hydrogels with high water content, good load‐bearing property, low frictional behavior as well as excellent biocompatibility have been considered as promising cartilage replacement materials. However, the lack of sufficient mechanical properties and cell adhesion are two critical barriers for their application as cartilage substitutes. To address these problems, herein, methacrylated PVA with low degree of substitution of methacryloyl group has been synthesized first. Then, methacrylated PVA‐glycidyl methacrylate/hydroxyapatite (PVA‐GMA/Hap) nanocomposite hydrogels have been developed by the photopolymerization approach subsequently. Markedly, both pure PVA‐GMA hydrogel and PVA‐GMA/Hap nanocomposite hydrogels exhibit excellent performance in compressive tests, and they are undamaged during compressive stress–strain tests. Moreover, compared to pure PVA‐GMA hydrogels, 8.5‐fold, 7.4‐fold, and 14.2‐fold increase in fracture stress, Young's modulus and toughness, respectively, can be obtained for PVA‐GMA/Hap nanocomposite hydrogels with 10 wt % Hap nanoparticles. These enhancements can be ascribed to the intrinsic property of PVA‐GMA and strong hydrogen bonding interactions between PVA‐GMA chain and Hap nanoparticles. More interestingly, significant improvement in the cell adhesion can also be successfully achieved by incorporation of Hap nanoparticles. These biocompatible nanocomposite hydrogels have great potential to be used as cartilage substitutes.
dc.description.sponsorshipThis study was supported by National Natural Science Foundation of China (grant no. 51203123), the National Key Research and Development Program of China (no. 2016YFA0101102). P. Xiao acknowledges funding from the Australian Research Council Future Fellowship (FT170100301).
dc.format.mimetypeapplication/pdf
dc.language.isoen_AU
dc.publisherWiley
dc.rights© 2018 Wiley Periodicals, Inc
dc.sourceJournal of Polymer Science: Part A: Polymer Chemistry
dc.titlePhotocrosslinked methacrylated poly(vinyl alcohol)/hydroxyapatite nanocomposite hydrogels with enhanced mechanical strength and cell adhesion
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume57
dc.date.issued2019
local.identifier.absfor030306 - Synthesis of Materials
local.identifier.ariespublicationu5786633xPUB953
local.publisher.urlhttps://www.wiley.com/en-gb
local.type.statusPublished Version
local.contributor.affiliationZhou, Ding, Wuhan Textile University
local.contributor.affiliationDong, Qi, Wuhan Textile University
local.contributor.affiliationLiang, Kaili, Wuhan Textile University
local.contributor.affiliationXu, Weilin, Wuhan Textile University
local.contributor.affiliationZhou, Yingshan, Wuhan Textile University
local.contributor.affiliationXiao, Pu, College of Science, ANU
local.description.embargo2037-12-31
dc.relationhttp://purl.org/au-research/grants/arc/FT170100301
local.bibliographicCitation.issue18
local.bibliographicCitation.startpage1882
local.bibliographicCitation.lastpage1889
local.identifier.doi10.1002/pola.29263
local.identifier.absseo970103 - Expanding Knowledge in the Chemical Sciences
dc.date.updated2020-06-23T00:57:38Z
local.identifier.scopusID2-s2.0-85055712934
CollectionsANU Research Publications

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