Skip navigation
Skip navigation

Late-Stage Functionalization of Histidine in Unprotected Peptides

Noisier, Anaïs F. M; Johansson, Magnus J.; Knerr, Laurent; Hayes, Martin A.; Drury, William J.; Valeur, Eric; Malins, Lara; Gopalakrishnan, Ranganath

Description

The late‐stage functionalization (LSF) of peptides represents a valuable strategy for the design of potent peptide pharmaceuticals by enabling rapid exploration of chemical diversity and offering novel opportunities for peptide conjugation. While the C(sp2)−H activation of tryptophan (Trp) is well documented, the resurgence of radical chemistry is opening new avenues for the C−H functionalization of other aromatic side‐chains. Herein, we report the first example of LSF at C2 of histidine (His)...[Show more]

CollectionsANU Research Publications
Date published: 2019
Type: Journal article
URI: http://hdl.handle.net/1885/211329
Source: Angewandte Chemie
DOI: 10.1002/anie.201910888

Download

File Description SizeFormat Image
01_Noisier_Late-Stage_Functionalization_2019.pdf3.44 MBAdobe PDF    Request a copy


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator