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Cytotoxicity and Anti-inflammatory Properties of Apigenin-Derived Isolaxifolin

Chen, Yongsheng; Chen, Wan-Na; Hu, Nan; Banwell, Martin; Ma, Chenxi; Lan, Ping; Gardiner, Michael


The rare flavonoid isolaxifolin, a potent insecticide, has been touted as a potential grain-protecting agent. In order to assess any impact of this natural product on human health and to explore its various other biological properties, we have established a semisynthesis from the simpler but structurally related and more abundant natural product apigenin. The five-step reaction sequence has provided, for the first time, sufficient material for an indepth evaluation of the cytotoxic...[Show more]

CollectionsANU Research Publications
Date published: 2019
Type: Journal article
Source: Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b00113


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