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Quinoline-resistance reversing agents for the malaria parasite Plasmodium falciparum

Van Schalkwyk, Donelly; Egan, T J


Resistance to quinoline antimalarials, especially to chloroquine and mefloquine has had a major impact on the treatment of malaria worldwide. In the period since 2000, significant progress has been made in understanding the origins of chloroquine resistance and to a lesser extent mefloquine resistance in Plasmodium falciparum. Chloroquine resistance correlates directly with mutations in the pfcrt gene of the parasite, while changes in another gene, pfmdr1, may also be related to chloroquine...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
Source: Drug Resistance Updates
DOI: 10.1016/j.drup.2006.09.002


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