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A composite polynomial approach for analyzing the indefinite self-association of macromolecules studied by sedimentation equilibrium

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Hall, Damien

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A different approach is described for analyzing sedimentation equilibrium experiments of indefinitely self-associating systems. The procedure involves application of conservation of mass criteria, along with local evaluation of the weight average molar mass, to generate a polynomial based on a composite pseudo-independent variable. The outlined method does not depend upon non-linear regression to generate a solution, but instead requires evaluation of the roots of a high-order polynomial.

dc.contributor.authorHall, Damien
dc.date.accessioned2020-09-21T00:31:14Z
dc.identifier.issn0301-4622
dc.identifier.urihttp://hdl.handle.net/1885/210662
dc.description.abstractA different approach is described for analyzing sedimentation equilibrium experiments of indefinitely self-associating systems. The procedure involves application of conservation of mass criteria, along with local evaluation of the weight average molar mass, to generate a polynomial based on a composite pseudo-independent variable. The outlined method does not depend upon non-linear regression to generate a solution, but instead requires evaluation of the roots of a high-order polynomial.
dc.description.sponsorshipThis work was jointly funded by an Australian National University Senior Research Fellowship and an Osaka University Cross-Appointment as an Associate Professor. Further grant assistance was provided by the Osaka University Multiscale Structural Biology Program awarded to Prof. Junichi Takagi and Damien Hall.
dc.format.mimetypeapplication/pdf
dc.language.isoen_AU
dc.publisherElsevier
dc.rightsCrown Copyright © 2017 Published by Elsevier B.V.
dc.sourceBiophysical Chemistry
dc.titleA composite polynomial approach for analyzing the indefinite self-association of macromolecules studied by sedimentation equilibrium
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume228
dc.date.issued2017
local.identifier.absfor030699 - Physical Chemistry not elsewhere classified
local.identifier.ariespublicationu4485658xPUB651
local.publisher.urlhttps://www.elsevier.com/en-au
local.type.statusPublished Version
local.contributor.affiliationHall, Damien, College of Science, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.startpage10
local.bibliographicCitation.lastpage16
local.identifier.doi10.1016/j.bpc.2017.06.002
local.identifier.absseo970103 - Expanding Knowledge in the Chemical Sciences
dc.date.updated2020-06-23T00:56:10Z
local.identifier.thomsonID000407980700002
CollectionsANU Research Publications

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