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A composite polynomial approach for analyzing the indefinite self-association of macromolecules studied by sedimentation equilibrium

Hall, Damien


A different approach is described for analyzing sedimentation equilibrium experiments of indefinitely self-associating systems. The procedure involves application of conservation of mass criteria, along with local evaluation of the weight average molar mass, to generate a polynomial based on a composite pseudo-independent variable. The outlined method does not depend upon non-linear regression to generate a solution, but instead requires evaluation of the roots of a high-order polynomial.

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
Source: Biophysical Chemistry
DOI: 10.1016/j.bpc.2017.06.002


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