The Application of Fragment-based Approaches to the Discovery of Drugs for Neglected Tropical Diseases
The term neglected tropical disease (NTD) is used to describe a diverse collection of communicable diseases prevalent in tropical and subtropical regions, which predominantly affect the poor. This chapter describes how fragment-based approaches are being applied in projects aimed at the discovery of new drugs for NTDs, either alone or in conjunction with high-throughput screening. It presents examples, classified according to pathogen, to highlight the power of fragment-based approaches to...[Show more]
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