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Multidrug Resistance in Neisseria gonorrhoeae: Identification of Functionally Important Residues in the MtrD Efflux Protein

Chitsaz, Mohsen; Booth, Lauren; Blyth, Mitchell; O'Mara, Megan; Brown, Melissa


A key mechanism that Neisseria gonorrhoeae uses to achieve multidrug resistance is the expulsion of structurally different antimicrobials by the MtrD multidrug efflux protein. MtrD resembles the homologous Escherichia coli AcrB efflux protein with several common structural features, including an open cleft containing putative access and deep binding pockets proposed to interact with substrates. A highly discriminating N. gonorrhoeae strain, with the MtrD and NorM multidrug efflux pumps...[Show more]

CollectionsANU Research Publications
Date published: 2019
Type: Journal article
Source: mBio
DOI: 10.1128/mBio.02277-19
Access Rights: Open Access


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