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Cofactor F420-dependent enzymes: An under-explored resource for asymmetric redox biocatalysis

Shah, Mihir V.; Antoney, James; Kang, Suk; Warden, Andrew C; Hartley, Carol J; Nazem-Bokaee, Hadi; Jackson, Colin; Scott, Colin


The asymmetric reduction of enoates, imines and ketones are among the most important reactions in biocatalysis. These reactions are routinely conducted using enzymes that use nicotinamide cofactors as reductants. The deazaflavin cofactor F420 also has electrochemical properties that make it suitable as an alternative to nicotinamide cofactors for use in asymmetric reduction reactions. However, cofactor F420-dependent enzymes remain under-explored as a resource for biocatalysis. This review...[Show more]

CollectionsANU Research Publications
Date published: 2019
Type: Journal article
Source: Catalysts
DOI: 10.3390/catal9100868
Access Rights: Open Access


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