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Kistamicin biosynthesis reveals the biosynthetic requirements for production of highly crosslinked glycopeptide antibiotics

Greule, Anja; Izoré, Thierry; Iftime, Dumitrita; Tailhades, Julien; Schoppet, Melanie; Zhao, Yongwei; Peschke, Madeleine; Ahmed, Iftekhar; Kulik, Andreas; Adamek, Martina; Kaczmarski, Joe Alexander; Jackson, Colin

Description

Kistamicin is a divergent member of the glycopeptide antibiotics, a structurally complex class of important, clinically relevant antibiotics often used as the last resort against resistant bacteria. The extensively crosslinked structure of these antibiotics that is essential for their activity makes their chemical synthesis highly challenging and limits their production to bacterial fermentation. Kistamicin contains three crosslinks, including an unusual 15- membered A-O-B ring, despite...[Show more]

CollectionsANU Research Publications
Date published: 2019
Type: Journal article
URI: http://hdl.handle.net/1885/210581
Source: Nature Communications
DOI: 10.1038/s41467-019-10384-w
Access Rights: Open Access

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