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Tandem Ullmann-Goldberg Cross-Coupling/Cyclopalladation-Reductive Elimination Reactions and Related Sequences Leading to Polyfunctionalized Benzofurans, Indoles, and Phthalanes

Khan, Faiyaz; Fatima, Mehvish; Shirzaei, Moheb; VO, Yen Thi-Hoang; Amarasiri, Madushani; Banwell, Martin; Ma, Chenxi; Ward, Jas; Gardiner, Michael


On exposure to a combination of Cu[I]- and Pd[0]-based catalysts, compounds such as 1 and 7 engage in tandem Ullmann-Goldberg cross-coupling and cyclopalladation-reductive elimination reactions to give benzofurans such as 8. Related reactions involving hetero-Michael additions of o-halogenated phenols or anilines to propiolates and the Pd[0]-catalyzed cyclization of the resulting conjugates provide, in a one-pot process, alternately functionalized benzofurans, indoles, or phthalanes.

CollectionsANU Research Publications
Date published: 2019
Type: Journal article
Source: Organic Letters
DOI: 10.1021/acs.orglett.9b02235
Access Rights: Open Access


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