Tunable paramagnetic relaxation enhancements by [Gd(DPA) 3 ] 3- for protein structure analysis
Paramagnetic relaxation enhancements (PRE) present a powerful source of structural information in nuclear magnetic resonance (NMR) studies of proteins and protein-ligand complexes. In contrast to conventional PRE reagents that are covalently attached to the protein, the complex between gadolinium and three dipicolinic acid (DPA) molecules, [Gd(DPA)3]3-, can bind to proteins in a non-covalent yet site-specific manner. This offers straightforward access to PREs that can be scaled by using...[Show more]
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|Source:||Journal of Biomolecular NMR|
|01_Yagi_Tunable_paramagnetic_2010.pdf||588.32 kB||Adobe PDF||Request a copy|
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