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A structural and functional study of Gln147 deamidation in aA-crystallin, a site of modification in human cataract

Ray, Nicholas; Hall, Damien; Carver, John

Description

Deamidation of Glu147 in human αA-crystallin is common in aged cataractous lenses (Hains and Truscott, Invest. Ophthalmol. Vis. Sci. 2010, 51, 3107). Accordingly, this modification may have a causative effect in cataract. αA-crystallin is a small heat-shock molecular chaperone protein that prevents aggregation of proteins and is the principal defence against crystallin unfolding and aggregation in the ageing lens. Deamidated Q147E αA-crystallin was structurally characterised using a variety of...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
URI: http://hdl.handle.net/1885/210099
Source: Experimental Eye Research
DOI: 10.1016/j.exer.2017.05.005

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