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RNA-binding proteins in Mendelian disease

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Castello, Alfredo; Fischer, Bernd; Hentze, Matthias; Preiss, Thomas

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RNA-binding proteins (RBPs) control all aspects of RNA fate, and defects in their function underlie a broad spectrum of human pathologies. We focus here on two recent studies that uncovered the in vivo mRNA interactomes of human cells, jointly implicating

dc.contributor.authorCastello, Alfredo
dc.contributor.authorFischer, Bernd
dc.contributor.authorHentze, Matthias
dc.contributor.authorPreiss, Thomas
dc.date.accessioned2015-12-07T22:24:50Z
dc.identifier.issn0168-9525
dc.identifier.urihttp://hdl.handle.net/1885/21002
dc.description.abstractRNA-binding proteins (RBPs) control all aspects of RNA fate, and defects in their function underlie a broad spectrum of human pathologies. We focus here on two recent studies that uncovered the in vivo mRNA interactomes of human cells, jointly implicating
dc.publisherElsevier
dc.sourceTrends in Genetics
dc.subjectKeywords: initiation factor 4E; messenger RNA; ribonucleoprotein; ribosome RNA; RNA binding protein; transfer RNA; 3' untranslated region; complex formation; genetic association; genetic disorder; HeLa cell; human; in vivo study; mass spectrometry; Mendelian diseas Disease genetics; Gene set enrichment; Interactome capture; Mass spectrometry; MRNA metabolism; Proteomics; RNA-binding domain; RNA-binding protein
dc.titleRNA-binding proteins in Mendelian disease
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume29
dc.date.issued2013
local.identifier.absfor060114 - Systems Biology
local.identifier.absfor060405 - Gene Expression (incl. Microarray and other genome-wide approaches)
local.identifier.absfor060408 - Genomics
local.identifier.ariespublicationu3526593xPUB15
local.type.statusPublished Version
local.contributor.affiliationCastello, Alfredo, European Molecular Biology Laboratory
local.contributor.affiliationFischer, Bernd, European Molecular Biology Laboratory
local.contributor.affiliationHentze, Matthias, EMBL, Germany
local.contributor.affiliationPreiss, Thomas, College of Medicine, Biology and Environment, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.issue5
local.bibliographicCitation.startpage318
local.bibliographicCitation.lastpage327
local.identifier.doi10.1016/j.tig.2013.01.004
local.identifier.absseo970106 - Expanding Knowledge in the Biological Sciences
local.identifier.absseo920102 - Cancer and Related Disorders
local.identifier.absseo920112 - Neurodegenerative Disorders Related to Ageing
dc.date.updated2016-02-24T10:16:44Z
local.identifier.scopusID2-s2.0-84876806808
local.identifier.thomsonID000319309100006
CollectionsANU Research Publications

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