Skip navigation
Skip navigation

The bioremediator glycerophosphodiesterase employs a non-processive mechanism for hydrolysis.

Hadler, Kieran S; Grahan, Lawrence R; Ollis, David; Schenk, Gerhard


Glycerophosphodiesterase (GpdQ) from Enterobacter aerogenes is a binuclear metallohydrolase that catalyzes the breakdown of a broad range of phosphate ester substrates, and it is of interest for its potential application in the destruction of organophosphate nerve agents and pesticides. The reaction mechanism of GpdQ has been proposed to involve a nucleophilic attack by a terminally bound hydroxide molecule. The hydroxide species bridging the two metal ions is suggested to activate the...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: Journal of Inorganic Biochemistry
DOI: 10.1016/j.jinorgbio.2009.10.012


File Description SizeFormat Image
01_Hadler_The_bioremediator_2010.pdf436.99 kBAdobe PDF    Request a copy

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator