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The bioremediator glycerophosphodiesterase employs a non-processive mechanism for hydrolysis.

Hadler, Kieran S; Grahan, Lawrence R; Ollis, David; Schenk, Gerhard

Description

Glycerophosphodiesterase (GpdQ) from Enterobacter aerogenes is a binuclear metallohydrolase that catalyzes the breakdown of a broad range of phosphate ester substrates, and it is of interest for its potential application in the destruction of organophosphate nerve agents and pesticides. The reaction mechanism of GpdQ has been proposed to involve a nucleophilic attack by a terminally bound hydroxide molecule. The hydroxide species bridging the two metal ions is suggested to activate the...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
URI: http://hdl.handle.net/1885/20984
Source: Journal of Inorganic Biochemistry
DOI: 10.1016/j.jinorgbio.2009.10.012

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