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Synthesis and kinetic testing of tetrahydropyrimidine-2-thione and pyrrole derivatives as inhibitors of the metallo-β-lactamase from Klebsiella pneumonia and Pseudomonas aeruginosa

Hussein, Waleed M; Fatahala, Samar; Mohamed, Zainab M; McGeary, Ross Peter; Schenk, Gerhard; Ollis, David; Mohamed, Mosaad S.


Metallo-β-lactamases (MBLs), produced by an increasing number of bacterial pathogens, facilitate the hydrolysis of many commonly used β-lactam antibiotics. There are no clinically useful antagonists against MBLs. Two sets of tetrahydropyrimidine-2-thion

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: Chemical Biology and Drug Design
DOI: 10.1111/j.1747-0285.2012.01440.x


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