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Small neutral Gd(iii) tags for distance measurements in proteins by double electron–electron resonance experiments

Mahawaththa, Mithun C.; Lee, Michael D.; Giannoulis, Angeliki; Adams, Luke A.; Feintuch, Akiva; Swarbrick, James D.; Graham, Bim; Nitsche, Christoph; Goldfarb, Daniella; Otting, Gottfried


Spin labels containing a Gd(III) ion have become important for measuring nanometer distances in proteins by double electron–electron resonance (DEER) experiments at high EPR frequencies. The distance resolution and sensitivity of these measurements strongly depend on the Gd(III) tag used. Here we report the performance of two Gd(III) tags, propargyl-DO3A and C11 in DEER experiments carried out at W-band (95 GHz). Both tags are small, uncharged and devoid of bulky hydrophobic pendants. The...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
Source: Physical Chemistry Chemical Physics
DOI: 10.1039/C8CP03532F
Access Rights: Open Access


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