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A multifunctional surfactant catalyst inspired by hydrolases

Nothling, Mitchell D; Xiao, Zeyun; Hill, Nicholas S; Blyth, Mitchell; Bhaskaran, Ayana; Sani, Marc-Antoine; Espinosa-Gomez, Andrea; Ngov, Kevin; White, Jonathan; Buscher, Tim; Separovic, Frances; O'Mara, Megan; Coote, Michelle; Luke, Connal


The remarkable power of enzymes to undertake catalysis frequently stems from their grouping of multiple, complementary chemical units within close proximity around the enzyme active site. Motivated by this, we report here a bioinspired surfactant catalyst that incorporates a variety of chemical functionalities common to hydrolytic enzymes. The textbook hydrolase active site, the catalytic triad, is modeled by positioning the three groups of the triad (-OH, -imidazole, and -CO2H) on a single,...[Show more]

CollectionsANU Research Publications
Date published: 2020
Type: Journal article
Source: Science advances
DOI: 10.1126/sciadv.aaz0404
Access Rights: Open Access


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