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Type 2 Diabetes, Cardiovascular Disease, and the Evolutionary Paradox of the Polycystic Ovary Syndrome: A Fertility First Hypothesis

Corbett, Stephen J; McMichael, Anthony; Prentice, Andrew M


Worldwide, the high prevalence of the Polycystic Ovary Syndrome (PCOS), a heritable cause of ovarian infertility, is an evolutionary paradox, which provides insight into the susceptibility of well-fed human populations to cardiovascular disease and diabetes. We propose that PCOS, Type 2 diabetes (T2D) and the Metabolic Syndrome are modern phenotypic expressions of a metabolic genotype attuned to the dietary and energetic conditions of the Pleistocene. This metabolic "Fertility First" rather...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: American Journal of Human Biology
DOI: 10.1002/ajhb.20937


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