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A cooperative interaction between LPHN3 and 11q doubles the risk for ADHD

Jain , M; Velez, Jorge I; Acosta, Maria T; Palacio, LG; Balog, J.; Roessler, Erich; Pineda, David A; Londono, Ana C; Palacio, Juan David; Arbelaez, Andres; Arcos-Burgos, Mauricio (Oscar)


In previous studies of a genetic isolate, we identified significant linkage of attention deficit hyperactivity disorder (ADHD) to 4q, 5q, 8q, 11q and 17p. The existence of unique large size families linked to multiple regions, and the fact that these families came from an isolated population, we hypothesized that two-locus interaction contributions to ADHD were plausible. Several analytical models converged to show significant interaction between 4q and 11q (P<1 × 10-8) and 11q and 17p (P<1 ×...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: Molecular Psychiatry
DOI: 10.1038/Mp.2011.59


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