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Interplay of dFOXO and Two ETS-Family Transcription Factors Determines Lifespan in Drosophila melanogaster

Alic, Nazif; Giannakou, MMaria; Papatheodorou, Irene; Hoddinott, Matthew; Andrews, Thomas Daniel; Bolukbasi, Ekin; Partridge, Linda


Forkhead box O (FoxO) transcription factors (TFs) are key drivers of complex transcriptional programmes that determine animal lifespan. FoxOs regulate a number of other TFs, but how these TFs in turn might mediate the anti-ageing programmes orchestrated by FoxOs in vivo is unclear. Here, we identify an E-twenty six (ETS)-family transcriptional repressor, Anterior open (Aop), as regulated by the single Drosophila melanogaster FoxO (dFOXO) in the adult gut. AOP, the functional orthologue of the...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
Source: PLoS Genetics
DOI: 10.1371/journal.pgen.1004619
Access Rights: Open Access


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