Trafficking and function of Maurer's clefts proteins and Maurer's clefts biogenesis
Plasmodium falciparum, the most lethal malaria parasite species for humans, vastly remodels the mature human red blood cell (RBC) upon invasion for its own survival. The severe pathology of P. falciparum infection is associated with the display of the major virulence protein, P. falciparum erythrocyte membrane protein 1 (PfEMP1) on the surface of the infected RBC and the subsequent cytoadhesion of infected cells in the microvasculature of host organs. This trafficking process is dependent on...[Show more]
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