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Transcriptional response of Caenorhabditis elegans when exposed to Shigella flexneri

Somasiri, Pamodha; Behm, Carolyn; Adamski, Marcin; Wen, Jiayu; Verma, Naresh


In recent years, researchers have begun to use Caenorhabditis elegans as a potential animal model to study Shigella pathogenesis. This study aims to further develop this model using RNA-sequencing to understand which pathways/cellular characteristics are affected and potentially cause death in Shigella-exposed worms. We identified 1631 differentially expressed genes in Shigella-exposed worms (6 h exposure). A number of these genes encode proteins involved in fatty-acid β-oxidation (FAO),...[Show more]

CollectionsANU Research Publications
Date published: 2019-05-21
Type: Journal article
Source: Genomics
DOI: 10.1016/j.ygeno.2019.05.016
Access Rights: Open Access


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