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Overcoming synthetic challenges in targeting coenzyme A biosynthesis with the antimicrobial natural product CJ-15,801

Domingo, Riyad; van der Westhuyzen, Renier; Hamann, Anton R.; Mostert, Konrad J.; Barnard, Leanne; Paquet, Tanya; Tjhin, Erick; Saliba, Kevin; van Otterlo, Willem A. L.; Strauss, Erick


The biosynthesis of the essential metabolic cofactor coenzyme A (CoA) has been receiving increasing attention as a new target that shows potential to counter the rising resistance to established antimicrobials. In particular, phosphopantothenoylcysteine synthetase (PPCS)—the second CoA biosynthesis enzyme that is found as part of the bifunctional CoaBC protein in bacteria, but is monofunctional in eukaryotes—has been validated as a target through extensive genetic knockdown studies in...[Show more]

CollectionsANU Research Publications
Date published: 2019
Type: Journal article
Source: MedChemComm
DOI: 10.1039/c9md00312f


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