Domingo, Riyad; van der Westhuyzen, Renier; Hamann, Anton R.; Mostert, Konrad J.; Barnard, Leanne; Paquet, Tanya; Tjhin, Erick; Saliba, Kevin; van Otterlo, Willem A. L.; Strauss, Erick
The biosynthesis of the essential metabolic cofactor coenzyme A (CoA) has been receiving increasing
attention as a new target that shows potential to counter the rising resistance to established antimicrobials.
In particular, phosphopantothenoylcysteine synthetase (PPCS)—the second CoA biosynthesis enzyme that
is found as part of the bifunctional CoaBC protein in bacteria, but is monofunctional in eukaryotes—has
been validated as a target through extensive genetic knockdown studies in...[Show more]
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