Skip navigation
Skip navigation

Characterization of the apicoplast-localized enzyme TgUroD in Toxoplasma gondii reveals a key role of the apicoplast in heme biosynthesis

Tjhin, Edwin; Hayward, Jenni; McFadden, Geoffrey I.; van Dooren, Giel

Description

Apicomplexan parasites such as Toxoplasma gondii possess an unusual heme biosynthesis pathway whose enzymes localize to the mitochondrion, cytosol, or apicoplast, a nonphotosynthetic plastid present in most apicomplexans. To characterize the involvement of the apicoplast in the T. gondii heme biosynthesis pathway, we investigated the role of the apicoplastlocalized enzyme uroporphyrinogen III decarboxylase (TgUroD). We found that TgUroD knockdown impaired parasite proliferation, decreased free...[Show more]

CollectionsANU Research Publications
Date published: 2019-12-30
Type: Journal article
URI: http://hdl.handle.net/1885/206330
Source: Journal of Biological Chemistry
DOI: 10.1074/jbc.RA119.011605
Access Rights: Open Access

Download

File Description SizeFormat Image
Tjhin_et_al_2020.pdfAuthor Accepted Manuscript3.07 MBAdobe PDFThumbnail


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator