CARD11 is dispensable for homeostatic responses and suppressive activity of peripherally induced FOXP3+ regulatory T cells
-
Altmetric Citations
Policheni, Antonia; Horikawa, Keisuke; Milla, Liz; Kofler, Jennifer; Bouillet, Philippe; Belz, Gabrielle; O'Reilly, Lorraine A.; Goodnow, Christopher C.; Strasser, Andreas; Gray, Daniel H. D.
Description
FOXP3+ regulatory T (Treg) cells are essential for immunological tolerance and immune homeostasis. Despite a great deal of interest in modulating their number and function for the treatment of autoimmune disease or cancer, the precise mechanisms that control the homeostasis of Treg cells remain unclear. We report a new ENU-induced mutant mouse, lack of costimulation (loco), with atopic dermatitis and Treg cell deficiency typical of Card11 loss-of-function mutants. Three distinct single...[Show more]
Collections | ANU Research Publications |
---|---|
Date published: | 2019-05-14 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/206322 |
Source: | Immunology and Cell Biology |
DOI: | 10.1111/imcb.12268 |
Download
File | Description | Size | Format | Image |
---|---|---|---|---|
01_Policheni_CARD11_is_dispensable_for_2019.pdf | 1.46 MB | Adobe PDF | Request a copy |
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.
Updated: 17 November 2022/ Responsible Officer: University Librarian/ Page Contact: Library Systems & Web Coordinator