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Convergent evolution of a vertebrate-like methylome in a marine sponge

de Mendoza, Alex; Hatleberg , William L.; Pang, Kevin; Leininger, Sven; Bogdanovic, Ozren; Pflueger, Jahnvi; Buckberry , Sam; Technau , Ulrich; Hejnol , Andreas; Adamska, Maja; Degnan , Bernard M.


Vertebrates have highly methylated genomes at CpG positions, whereas invertebrates have sparsely methylated genomes. This increase in methylation content is considered a major regulatory innovation of vertebrate genomes. However, here we report that a sponge, proposed as the potential sister group to the rest of animals, has a highly methylated genome. Despite major differences in genome size and architecture, we find similarities between the independent acquisitions of the hypermethylated...[Show more]

CollectionsANU Research Publications
Date published: 2019-09-26
Type: Journal article
Source: Nature Ecology & Evolution
DOI: 10.1038/s41559-019-0983-2


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