Overcoming insecticide resistance through computational inhibitor design
-
Altmetric Citations
Correy, Galen; Zaidman, Daniel; Harmelin, Alon; Carvalho, Silvia; Mabbitt, Peter; Calaora, Viviane; James, Peter J.; Kotze, Andrew; Jackson, Colin; London, Nir
Description
Insecticides allow control of agricultural pests and disease vectors and are vital for global food security and health. The evolution of resistance to insecticides, such as organophosphates (OPs), is a serious and growing concern. OP resistance often involves sequestration or hydrolysis of OPs by carboxylesterases. Inhibiting carboxylesterases could, therefore, restore the effectiveness of OPs for which resistance has evolved. Here, we use covalent virtual screening to produce nano-/picomolar...[Show more]
Collections | ANU Research Publications |
---|---|
Date published: | 2019-10-01 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/205932 |
Source: | PNAS - Proceedings of the National Academy of Sciences of the United States of America |
DOI: | 10.1073/pnas.1909130116 |
Access Rights: | Open Access via publisher site |
Download
File | Description | Size | Format | Image |
---|---|---|---|---|
01_Correy_Overcoming_insecticide_2019.pdf | 1.6 MB | Adobe PDF | Request a copy |
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.
Updated: 17 November 2022/ Responsible Officer: University Librarian/ Page Contact: Library Systems & Web Coordinator