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Overcoming insecticide resistance through computational inhibitor design

Correy, Galen; Zaidman, Daniel; Harmelin, Alon; Carvalho, Silvia; Mabbitt, Peter; Calaora, Viviane; James, Peter J.; Kotze, Andrew; Jackson, Colin; London, Nir

Description

Insecticides allow control of agricultural pests and disease vectors and are vital for global food security and health. The evolution of resistance to insecticides, such as organophosphates (OPs), is a serious and growing concern. OP resistance often involves sequestration or hydrolysis of OPs by carboxylesterases. Inhibiting carboxylesterases could, therefore, restore the effectiveness of OPs for which resistance has evolved. Here, we use covalent virtual screening to produce nano-/picomolar...[Show more]

CollectionsANU Research Publications
Date published: 2019-10-01
Type: Journal article
URI: http://hdl.handle.net/1885/205932
Source: PNAS - Proceedings of the National Academy of Sciences of the United States of America
DOI: 10.1073/pnas.1909130116

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