FAD-sequestering proteins protect mycobacteria against hypoxic and oxidative stress
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Harold, Liam K.; Antoney, James; Ahmed, Fathimath; Hards, Kiel; Carr, Paul D.; Rapson, Trevor D.; Greening, Chris; Jackson, Colin; Cook, Greg
Description
The ability to persist in the absence of growth triggered by low oxygen levels is a critical process for the survival of mycobacterial species in many environmental niches. MSMEG_5243 (fsq), a gene of unknown function in Mycobacterium smegmatis, is up-regulated in response to hypoxia and regulated by DosRDosS/DosT, an oxygen- and redox-sensing two-component system that is highly conserved in mycobacteria. In this communication, we demonstrate that MSMEG_5243 is a flavin-sequestering protein and...[Show more]
Collections | ANU Research Publications |
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Date published: | 2018-12-19 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/205860 |
Source: | Journal of Biological Chemistry |
DOI: | 10.1074/jbc.RA118.006237 |
Access Rights: | Open Access |
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01_Harold_FAD-sequestering_proteins_2019.pdf | 2.56 MB | Adobe PDF | Request a copy |
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