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Localized two-photon photoswitching of Optovin in rat cortical neurons

Kheradpezhouh, Ehsan; Choy, Julian; Arabzadeh, Ehsan; Daria, Vincent


Photoswitching molecules are widely used to control neuronal activity by activation of endogenous cellular channels and receptors. Optovin is a photoswitching molecule that targets the cation channel transient receptor potential ankyrin 1 (TRPA1). In zebrafish, bulk single-photon photoswitching of Optovin produced behavioural responses associated with TRPA1 activation. We recently found that TRPA1 is widely expressed in the rodent brain particularly in cortical pyramidal neurons and...[Show more]

CollectionsANU Research Publications
Date published: 2019-04-12
Type: Journal article
Source: Journal of Physics D: Applied Physics
DOI: 10.1088/1361-6463/ab1333


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