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Oxidative stress, inflammation and risk of neurodegeneration in a population sample

Cherbuin, Nicolas; Walsh, Erin; Baune, B. T.; Anstey, Kaarin

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Background and purpose Inflammation and oxidative stress (OS) have been clearly linked to neurodegeneration. However, studies investigating the associations between peripheral markers of inflammation and cognitive decline have produced mixed results. This is possibly due to the fact that markers are typically tested individually despite the fact that biologically they function interactively. Thus, the aim of this study was to investigate the association between a combination of OS/inflammation...[Show more]

dc.contributor.authorCherbuin, Nicolas
dc.contributor.authorWalsh, Erin
dc.contributor.authorBaune, B. T.
dc.contributor.authorAnstey, Kaarin
dc.date.accessioned2020-07-07T00:23:15Z
dc.identifier.issn1351-5101
dc.identifier.urihttp://hdl.handle.net/1885/205852
dc.description.abstractBackground and purpose Inflammation and oxidative stress (OS) have been clearly linked to neurodegeneration. However, studies investigating the associations between peripheral markers of inflammation and cognitive decline have produced mixed results. This is possibly due to the fact that markers are typically tested individually despite the fact that biologically they function interactively. Thus, the aim of this study was to investigate the association between a combination of OS/inflammation markers and outcomes including mild cognitive impairment (MCI) diagnosis, cognitive decline and hippocampal atrophy. Methods Oxidative stress/inflammation status was assessed in 380 older community‐living individuals. Thirteen blood markers were assayed. Principal component analysis (PCA) of all markers was conducted to identify the more salient inflammatory components. Associations between significant principal components, MCI diagnosis, previous change in Mini‐Mental State Examination (MMSE) score and hippocampal atrophy were investigated through logistic and linear multiple regression. Results Two factors (PC1 and PC2) reflecting predominantly broad pro‐inflammatory activity and two factors (PC3 and PC4) reflecting predominantly OS activity were identified by PCA analysis. PC3 and PC4 were predictive of MCI. PC3 was also predictive of prior MMSE change. PC1, PC2 and PC3 were significantly associated with hippocampal atrophy. Conclusions Combined analysis of complex and interacting biomarkers revealed a protective association between antioxidant activity and MCI that is consistent with lifestyle factors shown to reduce risk of cognitive decline. OS and broad systemic inflammation were also found to be associated with hippocampal atrophy further highlighting the benefits of the PCA methodology applied in this study.
dc.description.sponsorshipThe study was supported by NHMRC Grant 973302, 179805, 157125, 1063907, 1002560.
dc.format.mimetypeapplication/pdf
dc.language.isoen_AU
dc.publisherWiley
dc.rights© European Academy of Neurology 2019
dc.sourceEuropean Journal of Neurology
dc.titleOxidative stress, inflammation and risk of neurodegeneration in a population sample
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume26
dc.date.issued2019
local.identifier.absfor110904 - Neurology and Neuromuscular Diseases
local.identifier.absfor111702 - Aged Health Care
local.identifier.ariespublicationu3102795xPUB5321
local.publisher.urlhttps://www.wiley.com/en-gb
local.type.statusAccepted Version
local.contributor.affiliationCherbuin, Nicolas, College of Health and Medicine, ANU
local.contributor.affiliationWalsh, Erin, College of Health and Medicine, ANU
local.contributor.affiliationBaune, B. T., University of Munster
local.contributor.affiliationAnstey, Kaarin, College of Health and Medicine, ANU
dc.relationhttp://purl.org/au-research/grants/nhmrc/973302
dc.relationhttp://purl.org/au-research/grants/nhmrc/179805
dc.relationhttp://purl.org/au-research/grants/nhmrc/157125
dc.relationhttp://purl.org/au-research/grants/nhmrc/1063907
dc.relationhttp://purl.org/au-research/grants/nhmrc/1002560
local.bibliographicCitation.issue11
local.bibliographicCitation.startpage1347
local.bibliographicCitation.lastpage1354
local.identifier.doi10.1111/ene.13985
local.identifier.absseo920502 - Health Related to Ageing
dc.date.updated2020-03-08T07:20:03Z
local.identifier.scopusID2-s2.0-85067434414
dcterms.accessRightsOpen Access
dc.provenancehttps://v2.sherpa.ac.uk/id/publication/7713..."Non-Commercial Institutional Repository" from SHERPA/RoMEO site (as at 15/07/2020). This is the peer reviewed version of the following article: [Cherbuin, N., et al. "Oxidative stress, inflammation and risk of neurodegeneration in a population sample." European journal of neurology 26.11 (2019): 1347-1354.], which has been published in final form at https://dx.doi.org/10.1111/ene.13985. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions
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