Dynamics of Lead Bioavailability and Speciation in Indoor Dust and X-ray Spectroscopic Investigation of the Link between Ingestion and Inhalation Pathways
Kastury, Farzana; Smith, Euan; Lombi, Enzo; Donnelley, Martin W.; Cmielewski, Patricia L.; Parsons, David W.; Noerpel, Matt; Scheckel, Kirk G.; Kingston, Andrew; Myers, Glenn; Paterson, David; de Jonge, Martin; Juhasz, Albert L.
Lead (Pb) exposure from household dust is a major childhood health concern because of its adverse impact on cognitive development. This study investigated the absorption kinetics of Pb from indoor dust following a single dose instillation into C57BL/6 mice. Blood Pb concentration (PbB) was assessed over 24 h, and the dynamics of particles in the lung and gastro-intestinal (GI) tract were visualized using X-ray fluorescence (XRF) microscopy. The influence of mineralogy on Pb absorption and...[Show more]
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