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A cluster-randomised controlled trial comparing school and community-based deworming for soil transmitted helminth control in school-age children: the CoDe-STH trial protocol

Clarke, Naomi E; Ng-Nguyen, Dinh; Traub, Rebecca; Clements, Archie; Halton, Kate; Anderson, Roy; Gray, Darren; Coffeng, Luc E; Kaldor, John M; Nery, Susana

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Background: Current guidelines and targets for soil-transmitted helminth (STH) control focus on school-based deworming for school-age children, given the high risk of associated morbidity in this age group. However, expanding deworming to all age groups may achieve improved STH control among both the community in general and school-age children, by reducing their risk of reinfection. This trial aims to compare school-based targeted deworming with community-wide mass deworming in terms of impact...[Show more]

dc.contributor.authorClarke, Naomi E
dc.contributor.authorNg-Nguyen, Dinh
dc.contributor.authorTraub, Rebecca
dc.contributor.authorClements, Archie
dc.contributor.authorHalton, Kate
dc.contributor.authorAnderson, Roy
dc.contributor.authorGray, Darren
dc.contributor.authorCoffeng, Luc E
dc.contributor.authorKaldor, John M
dc.contributor.authorNery, Susana
dc.date.accessioned2020-06-19T03:39:09Z
dc.date.available2020-06-19T03:39:09Z
dc.identifier.issn1471-2334
dc.identifier.urihttp://hdl.handle.net/1885/205391
dc.description.abstractBackground: Current guidelines and targets for soil-transmitted helminth (STH) control focus on school-based deworming for school-age children, given the high risk of associated morbidity in this age group. However, expanding deworming to all age groups may achieve improved STH control among both the community in general and school-age children, by reducing their risk of reinfection. This trial aims to compare school-based targeted deworming with community-wide mass deworming in terms of impact on STH infections among school-age children. Methods: The CoDe-STH (Community Deworming against STH) trial is a cluster-randomised controlled trial (RCT) in 64 primary schools in Dak Lak province, Vietnam. The control arm will receive one round of school-based targeted deworming with albendazole, while in the intervention arm, community-wide mass deworming with albendazole will be implemented alongside school-based deworming. Prevalence of STH infections will be measured in school-age children at baseline and 12 months following deworming. The primary outcome is hookworm prevalence in school-age children at 12 months, by quantitative PCR. Analysis will be intention-to-treat, with outcomes compared between study arms using generalised linear and non-linear mixed models. Additionally, cost-effectiveness of mass and targeted deworming will be calculated and compared, and focus group discussions and interviews will be used to assess acceptability and feasibility of deworming approaches. Individual based stochastic models will be used to predict the impact of mass and targeted deworming strategies beyond the RCT timeframe to assess the likelihood of parasite population 'bounce-back' if deworming is ceased due to low STH prevalence. Discussion: The first large-scale trial comparing mass and targeted deworming for STH control in South East Asia will provide key information for policy makers regarding the optimal design of STH control programs. Trial registration: ACTRN12619000309189.
dc.description.sponsorshipThis work is supported by the National Health & Medical Research Council, Australia (grant number APP1139561). LEC acknowledges funding from the Dutch Research Council (NWO, grant 016.Veni.178.023).
dc.format.mimetypeapplication/pdf
dc.language.isoen_AU
dc.publisherBioMed Central
dc.rights© The Author(s).
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceBMC Infectious Diseases
dc.titleA cluster-randomised controlled trial comparing school and community-based deworming for soil transmitted helminth control in school-age children: the CoDe-STH trial protocol
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume19
dc.date.issued2019
local.identifier.absfor111706 - Epidemiology
local.identifier.ariespublicationu3102795xPUB5212
local.publisher.urlhttps://www.biomedcentral.com/
local.type.statusPublished Version
local.contributor.affiliationClarke, Naomi E, University of New South Wales
local.contributor.affiliationNg-Nguyen, Dinh, Tay Nguyen University
local.contributor.affiliationTraub, Rebecca, University of Melbourne
local.contributor.affiliationClements , Archie , Curtin University
local.contributor.affiliationHalton, Kate , Queensland University of Technology
local.contributor.affiliationAnderson, Roy, Imperial College London
local.contributor.affiliationGray, Darren, College of Health and Medicine, ANU
local.contributor.affiliationCoffeng, Luc E, University Medical Center Rotterdam
local.contributor.affiliationKaldor, John M, University of New South Wales
local.contributor.affiliationNery, Susana, University of New South Wales
dc.relationhttp://purl.org/au-research/grants/nhmrc/1139561
local.bibliographicCitation.issue822
local.bibliographicCitation.startpage1
local.bibliographicCitation.lastpage10
local.identifier.doi10.1186/s12879-019-4449-6
local.identifier.absseo920501 - Child Health
dc.date.updated2020-01-19T07:28:09Z
local.identifier.scopusID2-s2.0-85072403076
dcterms.accessRightsOpen Access
dc.provenance© The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
dc.rights.licenseCreative Commons Attribution 4.0 International License
CollectionsANU Research Publications

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