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¹³⁵La as an Auger-electron emitter for targeted internal radiotherapy

Fonslet, J.; Lee, Boon; Tran, T. A.; Siragusa, M.; Jensen, M.; Kibedi, Tibor; Stuchbery, Andrew; Severin, G. W.

Description

¹³⁵La has favorable nuclear and chemical properties for Auger-based targeted internal radiotherapy. Here we present detailed investigations of the production, emissions, and dosimetry related to ¹³⁵La therapy. ¹³⁵La was produced by 16.5 MeV proton irradiation of metallic natBa on a medical cyclotron, and was isolated and purified by trap-and-release on weak cation-exchange resin. The average production rate was 407  ±  19 MBq µA−1 (saturation activity), and the radionuclidic purity was 98% at...[Show more]

dc.contributor.authorFonslet, J.
dc.contributor.authorLee, Boon
dc.contributor.authorTran, T. A.
dc.contributor.authorSiragusa, M.
dc.contributor.authorJensen, M.
dc.contributor.authorKibedi, Tibor
dc.contributor.authorStuchbery, Andrew
dc.contributor.authorSeverin, G. W.
dc.date.accessioned2020-06-16T03:49:43Z
dc.identifier.issn0031-9155
dc.identifier.urihttp://hdl.handle.net/1885/205190
dc.description.abstract¹³⁵La has favorable nuclear and chemical properties for Auger-based targeted internal radiotherapy. Here we present detailed investigations of the production, emissions, and dosimetry related to ¹³⁵La therapy. ¹³⁵La was produced by 16.5 MeV proton irradiation of metallic natBa on a medical cyclotron, and was isolated and purified by trap-and-release on weak cation-exchange resin. The average production rate was 407  ±  19 MBq µA−1 (saturation activity), and the radionuclidic purity was 98% at 20 h post irradiation. Chemical separation recovered  >  98 % of the ¹³⁵La with an effective molar activity of 70  ±  20 GBq µmol−1. To better assess cellular and organ dosimetry of this nuclide, we have calculated the x-ray and Auger emission spectra using a Monte Carlo model accounting for effects of multiple vacancies during the Auger cascade. The generated Auger spectrum was used to calculate cellular S-factors. ¹³⁵La was produced with high specific activity, reactivity, radionuclidic purity, and yield. The emission spectrum and the dosimetry are favorable for internal radionuclide therapy.
dc.description.sponsorshipThis work was supported by the European Union Seventh Framework Programme FP7/2007-2013 under Grant 602820 (Mathias), and by the Australian Research Council Discovery Grant DP14 0103317.
dc.format.extent10 pages
dc.format.mimetypeapplication/pdf
dc.language.isoen_AU
dc.publisherInstitute of Physics Publishing
dc.rights© 2017 Institute of Physics and Engineering in Medicine. http://ioppublishing.org/wp-content/uploads/2016/05/J-VAR-LF-0216-Author-Rights-New-5.pdf This is an author-created, un-copyedited version of an article accepted for publication/published in Physics in Medicine and Biology. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at DOI 10.1088/1361-6560/aa9b44 (Publisher journal website as of 16/6/2020)
dc.sourcePhysics in Medicine and Biology
dc.subjectlanthanum, radionuclide therapy, isotope production, La-135, Auger therapy
dc.title¹³⁵La as an Auger-electron emitter for targeted internal radiotherapy
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume63
dcterms.dateAccepted2017-11-17
dc.date.issued2017-12-29
local.identifier.absfor020202 - Nuclear Physics
local.identifier.ariespublicationa383154xPUB10275
local.identifier.ariespublicationOpen Access
local.publisher.urlhttp://www.iop.org/
local.type.statusAccepted Version
local.contributor.affiliationFonslet, J., Technical University of Denmark
local.contributor.affiliationLee, Boon, College of Science, The Australian National University
local.contributor.affiliationTran, T. A., Lund University
local.contributor.affiliationSiragusa, M., Technical University of Denmark
local.contributor.affiliationJensen, M., Technical University of Denmark
local.contributor.affiliationKibedi, Tibor, College of Science, The Australian National University
local.contributor.affiliationStuchbery, Andrew, College of Science, The Australian National University
local.contributor.affiliationSeverin, G. W., Technical University of Denmark
dc.relationhttp://purl.org/au-research/grants/arc/DP14 0103317
local.identifier.essn1361-6560
local.bibliographicCitation.issue1
local.bibliographicCitation.startpage1
local.bibliographicCitation.lastpage9
local.identifier.doi10.1088/1361-6560/aa9b44
local.identifier.absseo970102 - Expanding Knowledge in the Physical Sciences
dc.date.updated2019-11-25T07:20:12Z
local.identifier.scopusID2-s2.0-85040309258
dc.provenancehttp://sherpa.ac.uk/romeo/issn/0031-9155/ Author can archive post-print (ie final draft post-refereeing). Post-print on institutional website, institutional repository, subject-based repository, PubMed Central, non-commercial scientific social network or third party eprint servers after 12 months embargo (Sherpa/Romeo as of 16/6/2020)
CollectionsANU Research Publications

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