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¹³⁵La as an Auger-electron emitter for targeted internal radiotherapy

Fonslet, J.; Lee, Boon; Tran, T. A.; Siragusa, M.; Jensen, M.; Kibedi, Tibor; Stuchbery, Andrew; Severin, G. W.


¹³⁵La has favorable nuclear and chemical properties for Auger-based targeted internal radiotherapy. Here we present detailed investigations of the production, emissions, and dosimetry related to ¹³⁵La therapy. ¹³⁵La was produced by 16.5 MeV proton irradiation of metallic natBa on a medical cyclotron, and was isolated and purified by trap-and-release on weak cation-exchange resin. The average production rate was 407  ±  19 MBq µA−1 (saturation activity), and the radionuclidic purity was 98% at...[Show more]

CollectionsANU Research Publications
Date published: 2017-12-29
Type: Journal article
Source: Physics in Medicine and Biology
DOI: 10.1088/1361-6560/aa9b44


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