Role of Xanthine Oxidase in Dexamethasone-Induced Hypertension in Rats
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Ong, Sharon; Vickers, Janine; Zhang, Yi; McKenzie, Katja; Walsh, Claire; Whitworth, Judith
Description
1. Glucocorticoid-induced hypertension (GC-HT) in the rat is associated with nitric oxide-redox imbalance. 2. We studied the role of xanthine oxidase (XO), which is implicated in the production of reactive oxygen species, in dexamethasone-induced hypertension (dex-HT). 3. Thirty male Sprague-Dawley rats were divided randomly into four treatment groups: saline, dexamethasone (dex), allopurinol plus saline, and allopurinol plus dex. 4. Systolic blood pressures (SBP) and bodyweights were recorded...[Show more]
dc.contributor.author | Ong, Sharon | |
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dc.contributor.author | Vickers, Janine | |
dc.contributor.author | Zhang, Yi | |
dc.contributor.author | McKenzie, Katja | |
dc.contributor.author | Walsh, Claire | |
dc.contributor.author | Whitworth, Judith | |
dc.date.accessioned | 2015-12-07T22:23:06Z | |
dc.identifier.issn | 0305-1870 | |
dc.identifier.uri | http://hdl.handle.net/1885/20518 | |
dc.description.abstract | 1. Glucocorticoid-induced hypertension (GC-HT) in the rat is associated with nitric oxide-redox imbalance. 2. We studied the role of xanthine oxidase (XO), which is implicated in the production of reactive oxygen species, in dexamethasone-induced hypertension (dex-HT). 3. Thirty male Sprague-Dawley rats were divided randomly into four treatment groups: saline, dexamethasone (dex), allopurinol plus saline, and allopurinol plus dex. 4. Systolic blood pressures (SBP) and bodyweights were recorded each alternate day. Thymus weight was used as a marker of glucocorticoid activity, and serum urate to assess XO inhibition. 5. Dex increased SBP (110 ± 2-126 ± 3 mmHg; P < 0.001) and decreased thymus (P < 0.001) and bodyweights (P′ < 0.01). Allopurinol decreased serum urate from 76 ± 5 to 30 ± 3 μmol/L (P < 0.001) in saline and from 84 ± 13 to 28 ± 2 μmol/L in dex-treated (P < 0.01) groups. 6. Allopurinol did not prevent dex-HT. This, together with our previous findings that allopurinol failed to prevent adrenocorticotrophic hormone induced hypertension, suggests that XO activity is not a major determinant of GC-HT in the rat. | |
dc.publisher | Blackwell Science Asia | |
dc.source | Clinical and Experimental Pharmacology and Physiology | |
dc.subject | Keywords: allopurinol; dexamethasone; glucocorticoid; reactive oxygen metabolite; sodium chloride; urate; xanthine oxidase; animal experiment; animal tissue; article; body weight; comparative study; controlled study; hypertension; male; nonhuman; rat; systolic bloo Allopurinol; Dexamethasone; Glucocorticoid; Hypertension; Reactive oxygen species; Superoxide; Xanthine oxidase | |
dc.title | Role of Xanthine Oxidase in Dexamethasone-Induced Hypertension in Rats | |
dc.type | Journal article | |
local.description.notes | Imported from ARIES | |
local.identifier.citationvolume | 34 | |
dc.date.issued | 2007 | |
local.identifier.absfor | 110201 - Cardiology (incl. Cardiovascular Diseases) | |
local.identifier.ariespublication | u9505948xPUB12 | |
local.type.status | Published Version | |
local.contributor.affiliation | Ong, Sharon, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Vickers, Janine, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Zhang, Yi, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | McKenzie, Katja, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Walsh, Claire, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Whitworth, Judith, College of Medicine, Biology and Environment, ANU | |
local.description.embargo | 2037-12-31 | |
local.bibliographicCitation.startpage | 517 | |
local.bibliographicCitation.lastpage | 519 | |
local.identifier.doi | 10.1111/j.1440-1681.2007.04605.x | |
dc.date.updated | 2015-12-07T09:12:27Z | |
local.identifier.scopusID | 2-s2.0-33947660100 | |
Collections | ANU Research Publications |
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