Skip navigation
Skip navigation

Persistence of Epigenomic Effects After Recovery From Repeated Treatment With Two Nephrocarcinogens

Limonciel, Alice; van Breda, Simone G; Jiang, Xiaoqi; Tredwell, Greg; Wilmes, Anja; Aschauer, Lydia; Siskos, Alexandros P; Sachinidis, Agapios; Keun, Hector C.; Kopp-Schneider, Annette; de Kok, Theo M


The discovery of the epigenetic regulation of transcription has provided a new source of mechanistic understanding to long lasting effects of chemicals. However, this information is still seldom exploited in a toxicological context and studies of chemical effect after washout remain rare. Here we studied the effects of two nephrocarcinogens on the human proximal tubule cell line RPTEC/TERT1 using high-content mRNA microarrays coupled with miRNA, histone acetylation (HA) and DNA methylation (DM)...[Show more]

CollectionsANU Research Publications
Date published: 2018-12-03
Type: Journal article
Source: Frontiers in Genetics
DOI: 10.3389/fgene.2018.00558
Access Rights: Open Access


File Description SizeFormat Image
01_Limonciel_Persistence_of_Epigenomic_2018.pdf3.5 MBAdobe PDFThumbnail

This item is licensed under a Creative Commons License Creative Commons

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator