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Persistence of Epigenomic Effects After Recovery From Repeated Treatment With Two Nephrocarcinogens

Limonciel, Alice; van Breda, Simone G; Jiang, Xiaoqi; Tredwell, Greg; Wilmes, Anja; Aschauer, Lydia; Siskos, Alexandros P; Sachinidis, Agapios; Keun, Hector C.; Kopp-Schneider, Annette; de Kok, Theo M

Description

The discovery of the epigenetic regulation of transcription has provided a new source of mechanistic understanding to long lasting effects of chemicals. However, this information is still seldom exploited in a toxicological context and studies of chemical effect after washout remain rare. Here we studied the effects of two nephrocarcinogens on the human proximal tubule cell line RPTEC/TERT1 using high-content mRNA microarrays coupled with miRNA, histone acetylation (HA) and DNA methylation (DM)...[Show more]

CollectionsANU Research Publications
Date published: 2018-12-03
Type: Journal article
URI: http://hdl.handle.net/1885/204742
Source: Frontiers in Genetics
DOI: 10.3389/fgene.2018.00558
Access Rights: Open Access

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