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NMR methods for characterising protein structure in solution and solid state

Orton, Henry

Description

Unpaired electrons give rise to spatially dependent paramagnetic phenomena observable by NMR spectroscopy which can be utilised for molecular structure determination. Paramagnetic lanthanide protein-complexes display distance-dependent relaxation enhancements of nuclear spins which can be used to refine molecular structure, an area of great interest to structural biology and drug discovery. Such relaxation enhancements are usually measured using spin labels with slowly relaxing unpaired...[Show more]

CollectionsOpen Access Theses
Date published: 2020
Type: Thesis (PhD)
URI: http://hdl.handle.net/1885/204527
DOI: 10.25911/5ece42000eead

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