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Alzheimer's Environmental and Genetic Risk Scores are Differentially Associated With General Cognitive Ability and Dementia Severity

Andrews, Shea; McFall, G. Peggy; Dixon, Roger A.; Cherbuin, Nicolas; Eramudugolla, Ranmalee; Anstey, Kaarin

Description

Purpose: We investigated the association of the Australian National University Alzheimer’s Disease Risk Index (ANU-ADRI) and an Alzheimer disease (AD) genetic risk score (GRS) with cognitive performance. Methods: The ANU-ADRI (composed of 12 risk factors for AD) and GRS (composed of 25 AD risk loci) were computed in 1061 community-dwelling older adults. Participants were assessed on 11 cognitive tests and activities of daily living. Structural equation modeling was used to evaluate the...[Show more]

CollectionsANU Research Publications
Date published: 2019
Type: Journal article
URI: http://hdl.handle.net/1885/204298
Source: Alzheimer Disease and Associated Disorders
DOI: 10.1097/WAD.0000000000000292

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