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Pooling/bootstrap-based GWAS (pbGWAS) identifies new loci modifying the age of onset in PSEN1 p.Glu280Ala Alzheimer's disease

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Velez, Jorge I.; Chandrasekharappa, Settara C.; Henao, E.; Martinez, Ariel F.; Harper, U.; Jones, Marypat; Solomon, Benjamin D.; Lopez, L.; Garcia, Gloria; Aguirre-Acevedo, D. C.; Arcos-Burgos, Mauricio

Description

The literature on GWAS (genome-wide association studies) data suggests that very large sample sizes (for example, 50,000 cases and 50,000 controls) may be required to detect significant associations of genomic regions for complex disorders such as Alzheim

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
URI: http://hdl.handle.net/1885/20412
Source: Molecular Psychiatry
DOI: 10.1038/mp.2012.81

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