Lipopolysaccharide-Induced Expression of FAS Ligand in Cultured Immature Boar Sertoli Cells Through the Regulation of Pro-Inflammatory Cytokines and miR-187
Lipopolysaccharide (LPS) induces germ cell apoptosis, but its mechanism of action is not clear. One possibility is that LPS regulates the expression of FAS ligand (FASLG) in Sertoli cells, which will then influence germ cell apoptosis. In this study, LPS reduced the viability of cultured, immature boar Sertoli cells in a time‐ and dose‐dependent manner; enhanced the production of pro‐inflammatory cytokines including tumor necrosis factor α (TNFA), interleukin‐1β (IL1B), nitric oxide (NO), and...[Show more]
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|Source:||Molecular Reproduction and Development|
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