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Lipopolysaccharide-Induced Expression of FAS Ligand in Cultured Immature Boar Sertoli Cells Through the Regulation of Pro-Inflammatory Cytokines and miR-187

Wang, Yi; Zhang, Jiaojiao; Yang, Wei-Rong; Luo, Hong-Yan; Zhang, Jiahua; Wang, Xian-Zhong


Lipopolysaccharide (LPS) induces germ cell apoptosis, but its mechanism of action is not clear. One possibility is that LPS regulates the expression of FAS ligand (FASLG) in Sertoli cells, which will then influence germ cell apoptosis. In this study, LPS reduced the viability of cultured, immature boar Sertoli cells in a time‐ and dose‐dependent manner; enhanced the production of pro‐inflammatory cytokines including tumor necrosis factor α (TNFA), interleukin‐1β (IL1B), nitric oxide (NO), and...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
Source: Molecular Reproduction and Development
DOI: 10.1002/mrd.22534


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