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STAT3 regulates cytotoxicity of human CD57+ CD4+ T cells in blood and lymphoid follicles

AlShekaili, Jalila; Chand, Rochna; Lee, Cindy; Corley, Susan; Kwong, Kristy; Papa, Ilenia; Fulcher, David; Randall, Katrina; Leiding, Jennifer W; Ma, Cindy S.; Wilkins, Marc R.; Uzel, G; Goodnow, Christopher; Vinuesa, Carola; Tangye, Stuart; Cook, Matthew


A subset of human follicular helper T cells (TFH) cells expresses CD57 for which no distinct function has been identified. We show that CD57+ TFH cells are universally PD-1hi, but compared to their CD57− PD-1hi counterparts, express little IL-21 or IL-10 among others. Instead, CD57 expression on TFH cells marks cytotoxicity transcriptional signatures that translate into only a weak cytotoxic phenotype. Similarly, circulating PD-1+ CD57+ CD4+ T cells make less cytokine than their CD57− PD-1+...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
Source: Scientific Reports
DOI: 10.1038/s41598-018-21389-8
Access Rights: Open Access


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