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Ultrahigh-resolution optical coherence elastography through a micro-endoscope: towards in vivo imaging of cellular-scale mechanics

Fang, Q; Curatolo, Andrea; Wijesinghe, Philip; Yeow, Yen Ling; Hamzah, Juliana; Noble, Peter B; Karnowski, Karol; Sampson, David. D; Ganss, Ruth; Kim, Jun Ki; Lee, Woei Ming


In this paper, we describe a technique capable of visualizing mechanical properties at the cellular scale deep in living tissue, by incorporating a gradient-index (GRIN)-lens micro-endoscope into an ultrahigh-resolution optical coherence elastography system. The optical system, after the endoscope, has a lateral resolution of 1.6 µm and an axial resolution of 2.2 µm. Bessel beam illumination and Gaussian mode detection are used to provide an extended depth-of-field of 80 µm, which is a 4-fold...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
Source: Biomedical Optics Express
DOI: 10.1364/BOE.8.005127
Access Rights: Open Access


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