Ultrahigh-resolution optical coherence elastography through a micro-endoscope: towards in vivo imaging of cellular-scale mechanics
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Fang, Q; Curatolo, Andrea; Wijesinghe, Philip; Yeow, Yen Ling; Hamzah, Juliana; Noble, Peter B; Karnowski, Karol; Sampson, David. D; Ganss, Ruth; Kim, Jun Ki; Lee, Woei Ming
Description
In this paper, we describe a technique capable of visualizing mechanical properties at the cellular scale deep in living tissue, by incorporating a gradient-index (GRIN)-lens micro-endoscope into an ultrahigh-resolution optical coherence elastography system. The optical system, after the endoscope, has a lateral resolution of 1.6 µm and an axial resolution of 2.2 µm. Bessel beam illumination and Gaussian mode detection are used to provide an extended depth-of-field of 80 µm, which is a 4-fold...[Show more]
Collections | ANU Research Publications |
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Date published: | 2017 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/203410 |
Source: | Biomedical Optics Express |
DOI: | 10.1364/BOE.8.005127 |
Access Rights: | Open Access |
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01_Fang_Ultrahigh-resolution_optical_2017.pdf | 6.9 MB | Adobe PDF |
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