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Folic Acid Prevents and Partially Reverses Glucocorticoid-Induced Hypertension in the Rat

Miao, Yuchun; Zhang, Yi; Lim, Pek (Chloe); Kanjanapan, Yada; Mori, Trevor A; Croft, Kevin D; Earl, John; Lee, Sze; McKenzie, Katja; Hu, Lexian; Whitworth, Judith

Description

Background: To investigate the effect of folic acid on the increased pressure in rats treated with either adrenocorticotropic hormone (ACTH) or dexamethasone (Dex), and to further investigate the role of tetrahydrobiopterin (BH4) in any effect of folic acid by comparing the effect of BH4 with that of folic acid in Dex hypertension. Methods: Male Sprague-Dawley (SD) rats were treated with saline, subcutaneous ACTH (0.2 mg/kg/d) or Dex (10 μg/rat/d). Folic acid (0.04 g/L drinking) or BH4 (10...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
URI: http://hdl.handle.net/1885/20289
Source: American Journal of Hypertension
DOI: 10.1016/j.amjhyper.2006.08.007

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