Folic Acid Prevents and Partially Reverses Glucocorticoid-Induced Hypertension in the Rat
Background: To investigate the effect of folic acid on the increased pressure in rats treated with either adrenocorticotropic hormone (ACTH) or dexamethasone (Dex), and to further investigate the role of tetrahydrobiopterin (BH4) in any effect of folic acid by comparing the effect of BH4 with that of folic acid in Dex hypertension. Methods: Male Sprague-Dawley (SD) rats were treated with saline, subcutaneous ACTH (0.2 mg/kg/d) or Dex (10 μg/rat/d). Folic acid (0.04 g/L drinking) or BH4 (10...[Show more]
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|Source:||American Journal of Hypertension|
|01_Miao_Folic_Acid_Prevents_and_2007.pdf||239.96 kB||Adobe PDF||Request a copy|
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