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Heat stress-induced autophagy promotes lactate secretion in cultured immature boar Sertoli cells by inhibiting apoptosis and driving SLC2A3, LDHA, and SLC16A1 expression

Bao, Zi-Qiang; Liao, Ting-Ting; Yang, Wei-Rong; Wang, Yi; Luo, Hong-Yan; Wang, Xian-Zhong


This study aimed to determine whether heat stress (HS) could induce autophagy in immature boar Sertoli cells (SCs) and test whether HS-induced autophagy could regulate lactate secretion by SCs. Cultured immature boar SCs were incubated at 43 degrees C for 30 minutes. The ratio of LOB-II to LOB-I and the mRNA transcript levels of LOB showed time-dependent changes 0 to 48 hours after HS treatment, which peaked at 24 hours and increased by 30.25% or 260%, respectively, compared with control SCs....[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
Source: Theriogenology
DOI: 10.1016/j.theriogenology.2016.09.016


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