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Plasma levels of the soluble form of the Fc gamma RIIa receptor vary with receptor polymorphisms and are elevated in rheumatoid arthritis

Qiao, Jianlin; Dunne, E.; Wines, Bruce D.; Kenny, D.; McCarthy, Geraldine; Hogarth, Mark P.; Xu, Kailin; Andrews, Robert K.; Gardiner, Elizabeth

Description

Soluble forms of the low-affinity immunoglobulin receptor FcγRIIa (sFcγRIIa) lacking the cytoplasmic tail have been reported in plasma however the mechanism and functional consequences are unknown. This study aimed to evaluate mechanisms of FcγRIIa release compared to GPVI release from platelets, and examine whether genetic polymorphisms at positions 27 and 131 within FcγRIIa correlate with platelet FcγRIIa stability and function. Enzyme-linked immunosorbent assays (ELISAs) were used to measure...[Show more]

CollectionsANU Research Publications
Date published: 2019
Type: Journal article
URI: http://hdl.handle.net/1885/202360
Source: Platelets
DOI: 10.1080/09537104.2019.1647527
Access Rights: Open Access

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