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NAD+ cleavage activity by animal and plant TIR domains in cell death pathways

Horsefield, Shane; Burdett, Hayden; Zhang, XiaoXiao; Manik, Mohammad K.; Shi, Yun; Chen, Jian; Qi, Tiancong; Gilley, Jonathan; Lai, Jhih-Siang; Rank, Maxwell X.; Casey, Lachlan W.; Gu, Weixi; Rathjen, John; Williams, Simon


SARM1 (sterile alpha and TIR motif containing 1) is responsible for depletion of nicotinamide adenine dinucleotide in its oxidized form (NAD+) during Wallerian degeneration associated with neuropathies. Plant nucleotide-binding leucine-rich repeat (NLR) immune receptors recognize pathogen effector proteins and trigger localized cell death to restrict pathogen infection. Both processes depend on closely related Toll/interleukin-1 receptor (TIR) domains in these proteins, which, as we show,...[Show more]

CollectionsANU Research Publications
Date published: 2019-08-23
Type: Journal article
Source: Science
DOI: 10.1126/science.aax1911


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