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Five-coordinate MnIV intermediate in the activation of nature?s water splitting cofactor

Chrysina, Maria; Heyno, Eiri; Kutin, Yuri; Reus, Michael; Nilsson, Håkan; Nowaczyk, Marc M.; DeBeer, Serena; Messinger, Johannes; Neese, Frank; Lubitz, Wolfgang; Cox, Nicholas


Nature’s water splitting cofactor passes through a series of catalytic intermediates (S0-S4) before O-O bond formation and O2 release. In the second last transition (S2 to S3) cofactor oxidation is coupled to water molecule binding to Mn1. It is this activated, water-enriched all MnIV form of the cofactor that goes on to form the O-O bond, after the next light-induced oxidation to S4. How cofactor activation proceeds remains an open question. Here, we report a so far not described...[Show more]

CollectionsANU Research Publications
Date published: 2019
Type: Journal article
Source: PNAS - Proceedings of the National Academy of Sciences of the United States of America
DOI: 10.1073/pnas.1817526116
Access Rights: Open Access


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